2-Deoxy-D-glucose Powder
CAS: 154-17-6
Mtengo wa C6H12O5
MW: 164.16
Phukusi: 500g / thumba; 1kg / thumba
Chiyambi: China
Wonjezerani Luso: 100kg pamwezi
Zitsanzo Zilipo: Inde
Malipiro: T/T, LC kapena DA
Chitsimikizo: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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mankhwala Introduction
2-Deoxy-D-glucose ufa Wopereka
Xi'an Yihui Company ndi katswiri wopanga zabwino kwambiri 2-Deoxy-D-glucose ufa. Titha kupanga 2DG ndi 99.9%. Itha kugwiritsidwa ntchito muzakudya, mankhwala, zinthu zachipatala, kapena zodzoladzola ndikukwaniritsa miyezo ya USP, BP, EP, CP. Titha kukupatsirani zinthu zamtundu wapamwamba kwambiri pamitengo yampikisano kwambiri. Njira yanu yabwino kwambiri yoperekera 2DG yodziwika bwino ndi Xi'an Yihui Company!
Kodi 2-Deoxy-D-glucose powder ndi chiyani?
2- Deoxy- D-glucose ufa ndi mankhwala, mankhwala ake ndi C6H12O5 ndipo kulemera kwake kwa molekyulu ndi 164.16 g/ spook, CAS NO. ndi 154-17-6. Ndi shuga wa carbon 2 wofanana ndi glucose, koma alibe gulu la hydroxyl pamtundu wina wa carbon snippet, motero amatchedwa "deoxy" glucose. Ndi woyera demitasse ndi otsika kusungunuka m'madzi. XNUMXDG ndi chosokoneza kagayidwe kachakudya chomwe chingalepheretse kutengeka kwa shuga m'maselo ndikugwiritsa ntchito, zomwe zimapangitsa kutsika kwa ATP m'maselo.
Mankhwalawa amagwira ntchito kwambiri pama cell chotupa ndi tizilombo toyambitsa matenda tomwe timadalira shuga monga gawo lawo lalikulu la metabolism. Kugwiritsa ntchito 2DG kumatha kupangitsa kuti maselowa afe kapena kuchepetsa kukula kwawo. Kuphatikiza apo, 2DG imagwiritsidwa ntchito ngati chida mu kafukufuku wama neuroscience ndi metabolism chifukwa imatha kutsanzira kutha kwa kagayidwe kachakudya, kuwulula tsatanetsatane wa njira zama metabolic.
Kupezeka kwa 2-Deoxy-D-glucose kungayambike kumayambiriro kwa zaka za m'ma 1950. Panthawiyo, asayansi aku America Haskell Smith ndi Morris Ficher adapeza emulsion yotchedwa 2-deoxyglucose pomwe amaphunzira momwe ma cell amatengera shuga. Pambuyo pake, wasayansi wina, Takashi Otsuka, adapeza kuti glucose wa 2-deoxy amatha kulowerera m'maselo a glucose ndikuletsa kugawikana kwa ma cell pakuphatikizana kwa DNA.
Pambuyo pake, asayansi adachitanso kufufuza kwina 2-DG ufa ndikukhazikitsa kuti zitha kulepheretsa kukula kwa maselo ena ndi tizilombo toyambitsa matenda pomwe tili ndi zinthu zochepa pama cell abwinobwino.
Kuti awonjezere mphamvu ya 2DG, asayansi adayamba kupanga ndi kupanga zofananira. Pochita izi, adakhazikitsa kuti 2DG inali yosokoneza kwambiri kagayidwe kachakudya, yokhoza kulepheretsa kutengeka kwa shuga m'maselo ndikugwiritsa ntchito. Pakadali pano, 2DG yakhala chida chofunikira choyesera komanso mankhwala azachipatala.
Information Basic
dzina mankhwala | 2-Deoxy-D-glucose |
Dzina lina | kusakaniza kwa anomers; 2-Deoxy-D-Arabino; 2-deoxy-D-glucose kalasi iii; 2-deoxy-D-glucose giredi ii; Deoxy-d-glucose; 2-deoxyhexopyranose;2-deoxy-D-arabino-hexose; 2-deoxy-alpha-D-arabino-hexopyranose;2-deoxy-D-arabino-hexopyranose; 2-deoxy-D-glucose sigmaultra;2-deoxy-beta-D-arabino-hexopyranose |
CAS | 154-17-6 |
MF | C6H12O5 |
MW | 164.16 |
Malingaliro a kampani EINECS | 205-823-0 |
MDL No. | Mtengo wa MFCD00151328 |
Chiyeretso | 99% |
Kukhazikika | chokhazikika chikasungidwa pamikhalidwe yoyenera. |
kusungunuka | Zosungunuka pang'ono m'madzi |
ntchito | Gulu lamankhwala kapena kugwiritsidwa ntchito pofufuza. |
atanyamula | Monga mwa pempho lanu |
yosungirako | Kutentha kwapanyumba. |
Makhalidwe abwino |
Makhalidwe abwino
katunduyo | mfundo | Zotsatira za Analysis |
Maonekedwe | White kapena pafupifupi woyera ufa | White powder |
Chizindikiritso | zabwino | zabwino |
Kuzungulira kwapadera kwa kuwala | +45.0°--+47.5° | + 46.3 ° |
Zida zamtengo wapatali | 10 ppm pa | <10ppm |
Kutaya pa Kuuma | 1.0% Max | 0.30% |
Assay | 98.0% | 98.86% |
Wotsalira pakupereka | 0.2% Max | 0.07% |
Njira ya Synthesis
The kaphatikizidwe ndondomeko ya 2-deoxy-D-glucose ufar Zili ndi njira ziwiri:
Pa sitepe yoyamba, shuga amalowetsedwa ndi Knoevenagel condensation pochita ndi methyl vinyl ketone kuti apereke α, β-unsaturated carbonyl compound.
Mu gawo lachiwiri, tThe unsaturated compound imachepetsedwa kukhala 2-deoxy-D-shugage kudzera mu kuchepetsa hydrogenation.
Nawa njira zenizeni zomwe zimachitika:
Gawo loyamba reaction equation:
Glucose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound
Njira yoyamba yochitira zinthu:
Pansi pa zinthu zamchere, shuga ndi methyl vinyl ketone zimakhala ngati nucleophilic reagents ndipo zimadutsa Knoevenagel condensation mothandizidwa ndi thioacetone kapena sodium hydroxide, kutulutsa α, β-unsaturated carbonyl compound.
Gawo lachiwiri reaction equation:
α,β-unsaturated carbonyl compound + Hydrogen gas + Catalyst → 2-deoxy-D-glucose
Second step reaction mechanism:
Pamaso pa mpweya wa haidrojeni ndi chothandizira, unsaturated carbonyl emulsion imapangidwa ndi hydrogenated kuti itulutse 2-deoxy-D-glucose. Chothandizira chofanana ndi platinamu kapena kusamala chimagwiritsidwa ntchito poyankha hydrogenation iyi.
Zindikirani kuti ndi kalembedwe kamodzi kodziwika bwino kaphatikizidwe ka 2-deoxy-D-glucose. M'malo mwake, pali njira zina zosiyana zopangira, zofanana ndi kukonzanso kwa mankhwala a uracil ndi tizilombo toyambitsa matenda.
ndi chinthu chofunikira kwambiri chomwe chimagwiritsidwa ntchito kwambiri muzamankhwala, biotechnology, ndi makampani azakudya. Nazi ubwino wake:
Zilibe zotsatira poizoni pa thupi la munthu ndipo ali ndi kusankha kupha kwambiri maselo a khansa;
Ili ndi anti-virus, antifungal, anti-diabetes, anti-kunenepa kwambiri ndi zotsatira zina;
Ikhoza kutengeka ndi kupangidwa ndi thupi la munthu;
Itha kugwiritsidwa ntchito ngati chowongolera chojambulidwa ndi radiolabeled kapena DNA kukonza wothandizila mu biotechnology;
Itha kugwiritsidwa ntchito ngati chotsekemera chochepa cha calorie muzakudya;
Mwachidule, ndi zothandiza kwambiri pawiri ndi ntchito zosiyanasiyana.
Kodi 2 Deoxy Glucose Imagwira Ntchito Bwanji?
2 deoxy glucose (2DG) ndi analogue ya shuga yomwe ilibe gulu la hydroxyl pamalo a 2 a mphete ya glucose. Nthawi zambiri amagwiritsidwa ntchito pofufuza zasayansi ngati chida chofufuzira kagayidwe ka glucose ndi njira zake zofananira. Nazi zina mwa ntchito zake:
1. Katundu wa glycolysis 2DG amatengedwa ndi maselo kudzera mu zonyamula shuga ndi phosphorylated ndi hexokinase kuti 2DG-6-mankwala, amene sangakhale kutali zimapukusidwa ndi glycolysis. motero, 2DG imatha kuletsa mopikisana kutengeka kwa shuga ndi glycolysis, yomwe ndi gawo loyamba la metabolism yamphamvu.
2. Debaser of autophagy Autophagy ndi njira yochepetsera ma cell yomwe imathandiza kuti ma cell homeostasis asungidwe pobwezeretsa mapuloteni owonongeka kapena osafunika ndi organelles. 2DG imayambitsa autophagy mwa kulepheretsa chandamale cha mammalian cha rapamycin (mTOR) njira, zomwe zimapangitsa kuti ma jini okhudzana ndi autophagy ayambe kugwira ntchito.
3. Radiosensitizer: Maselo a khansa amakhala ndi shuga wambiri komanso glycolytic flux kuposa maselo abwinobwino, omwe amadziwika kuti Warburg effect. Chifukwa chake, 2DG imatha kupatsa chidwi ma cell a khansa ku radiotherapy poletsa glycolysis ndikuwonjezera kupsinjika kwa ma cell.
4. Kukonzanso zochitika za neurodegenerative mikhalidwe 2DG yawonetsedwa kuti imathandizira kuzindikira komanso kuchepetsa matenda a neuropathology m'zirombo za madandaulo a Alzheimer's ndi madandaulo a Parkinson. Izi zitha kukhudza kukulitsa kwa glucose metabolism muubongo, kuchepetsa kutupa kwa neuronal ndi kupsinjika kwa okosijeni.
5. Chida cholembera zilembo za kagayidwe kachakudya Chifukwa cha kapangidwe kake ngati shuga komanso kuthekera kophatikizana ndi glycolysis, 2-deoxy-d-glucose API Itha kugwiritsidwa ntchito ngati cholembera cha metabolic kuti iphunzire za kagayidwe kachakudya ka glucose-deduced motes m'maselo ndi ma apkins.
Powombetsa mkota,2-deoxy d glucose ili ndi ntchito zambiri zofunika pakufufuza kwasayansi, kuphatikiza ngati choletsa glycolysis, inducer of autophagy, radiosensitizer, kuthekera kochizira matenda a neurodegenerative, ndi chida cholembera zilembo zama metabolic. Kugwiritsa ntchito kwake kumakhala ndi zotsatirapo pazasayansi zoyambira komanso zamankhwala azachipatala.
Kunyamula & Kutumiza
Atanyamula:1kg / thumba zojambulazo; 5kg / katoni; 25kg / fiber ng'oma; kapena kulongedza monga pempho lanu.
Zosintha:
Chizindikiro chokhazikika
Katundu wosanjidwa
Makonda pazithunzi
Nthawi yotsogolera: Mkati mwa masiku atatu ogwira ntchito mutalandira malipiro.
Manyamulidwe
katunduyo | kuchuluka | ETA nthawi | Njira Yotumizira |
Wolemba Courier | Kg50kg | 7-15days | Fedex, DHL, UPS, TNT, EMS etc. Fast ndi yabwino |
Ndi Mlengalenga | 50kg ~ 200kg | 3-5days | Mofulumira komanso wotsika mtengo |
Panyanja | Kuchuluka kwakukulu | 20-35days | Njira yotsika mtengo |
malipiro Yaitali
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Phindu lathu
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Pomaliza
Mwachidule, monga katswiri 2-Deoxy-D-glucose ufa wopanga, tili ndi ukadaulo wapamwamba kwambiri, mwayi wokulirapo, mtundu wabwino kwambiri, zokumana nazo zambiri zopanga, ndi ntchito zabwino kwambiri. Zopindulitsa izi zidzapangitsa kuti ziwonekere mumpikisano wamsika ndikupeza chikhulupiliro ndi chithandizo chamakasitomala.
Ngati mukufuna kudziwa zambiri za 2-DG kapena mukufuna kugula, mutha kulumikizana nafe nthawi iliyonse. Tidzakuyankhani posachedwa tikawona uthengawo.
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